Bay State native Ellen Moran was named today as communications director for the Obama White House -- which we know is a very important job because we saw Toby Ziegler doing it on The West Wing. Moran was born in Amherst and went to Wheaton College; according to what I could dig up quickly, it appears that she graduated in Spring '88, and Wheaton began accepting boys (ick!) that Fall, so we can fairly say that she attended a Massachusetts all-women's college.
That makes her the second senior-level staffer who can make that claim: Mona Sutphen, Mount Holyoke '89, has been named deputy chief of staff. (That's Josh Lyman in The West Wing.)
Oh, yes, and it appears that Hillary Clinton nee Rodham, Wellesley '69, will be Secretary of State.